New Alzheimer’s Discovery Could Change How Scientists Fight the Disease

  • تاريخ النشر: منذ يوم زمن القراءة: دقيقة قراءة

ETH Zurich researchers identify a damaged protein disrupting cell energy and an experimental compound that blocks it.

The New Target Is Called GRK2

The Research Took Nearly 20 Years

GRK2 Exists in Two Different Forms

The Clusters Attack Mitochondria

A Destructive Feedback Loop Begins

Compound 10 Blocks the Clumping

Alzheimer’s Markers Declined in Mice

The Drug Works Differently From Current Treatments

Unexpected Effects Appeared Outside the Brain

Human Trials Are Still a Long Way Off

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For decades, Alzheimer’s research has concentrated heavily on amyloid plaques and tau tangles, the abnormal proteins that accumulate in affected brains. A new study from ETH Zurich now points to another possible driver: a damaged form of the protein GRK2 that disrupts the energy-producing machinery inside nerve cells.

The researchers also developed an experimental treatment called Compound 10, which interrupted this damaging process in cells and mice. The results are promising, but the compound has not been tested in people and is not an approved Alzheimer’s treatment. The study was published in Cell Reports Medicine on March 26, 2026.

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