Scientists May Have Found a Way to Heal Damaged Kidneys

  • تاريخ النشر: منذ ساعتين زمن القراءة: دقيقة قراءة

The finding is promising, but it is not yet a treatment for people with kidney disease, and no human kidney trial has begun.

Researchers Identified a Brake on Kidney Repair

Damaged Tissue Was Blocking Healthy Cells

Human Biopsies Supported the Biological Link

The Team Used More Than One Injury Model

Removing ENPP1 Improved Natural Recovery

AD-NP1 Reproduced the Effect With a Drug

Improvement Appeared Within Seven Days

Less Scarring Could Be Especially Important

The Drug Was First Developed for the Heart

Human Kidney Treatment Remains a Future Goal

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Kidneys can recover after some injuries, but severe damage often leaves scar tissue and reduced function instead of complete regeneration. UCLA researchers have now identified a protein that appears to help create that failure of repair.

Their experimental drug improved kidney recovery in mice by blocking the protein, known as ENPP1. The finding is promising, but it is not yet a treatment for people with kidney disease, and no human kidney trial has begun.

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